Conserved Signals of Ncrna Across 73 Genes Associated with Asd ebook
Conserved Signals of Ncrna Across 73 Genes Associated with Asd ebook
Conserved Signals of Ncrna Across 73 Genes Associated with Asd.cTheodor Rais
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Author: Theodor Rais
Number of Pages: 64 pages
Published Date: 21 May 2010
Publisher: LAP Lambert Academic Publishing
Publication Country: Germany
Language: English
Format: Pdf
ISBN: 9783838316765
File size: 17 Mb
File Name: conserved.signals.of.ncrna.across.73.genes.associated.with.asd.pdf
Download Link: conserved signals of ncrna across 73 genes associated with asd
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The Autistic Spectrum Disorders (ASD), are known for their considerable heterogenic clinical presentation. Linkage studies have pointed toward very diverse areas of the genome related to the brain and associated with ASD. We hypothesized that small non-coding RNA (ncRNA), like miRNA, siRNA or orphan snoRNAs, could be involved in the pathogenesis of ASD. A group of 73 genes associated with ASD were selected, proven through linkage studies, presence of biological markers (evidence of SNP's or haplotypes) or candidate genes association studies. A control group of 75 genes, which were predominantly expressed in non-brain tissues was selected. The results showed that the average number of conserved segments per intron in autism specific genes was 3.9, while it was 1.4 in the case of the genes minimally expressed in the brain. A non- parametric statistical test (Mann-Witney) showed a significant difference in degree of conservation between the two groups.
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Conserved Signals of Ncrna Across 73 Genes Associated with Asd.cTheodor Rais
Author: Theodor Rais
Number of Pages: 64 pages
Published Date: 21 May 2010
Publisher: LAP Lambert Academic Publishing
Publication Country: Germany
Language: English
Format: Pdf
ISBN: 9783838316765
File size: 17 Mb
File Name: conserved.signals.of.ncrna.across.73.genes.associated.with.asd.pdf
Download Link: conserved signals of ncrna across 73 genes associated with asd
---------------------------------------------------------------
The Autistic Spectrum Disorders (ASD), are known for their considerable heterogenic clinical presentation. Linkage studies have pointed toward very diverse areas of the genome related to the brain and associated with ASD. We hypothesized that small non-coding RNA (ncRNA), like miRNA, siRNA or orphan snoRNAs, could be involved in the pathogenesis of ASD. A group of 73 genes associated with ASD were selected, proven through linkage studies, presence of biological markers (evidence of SNP's or haplotypes) or candidate genes association studies. A control group of 75 genes, which were predominantly expressed in non-brain tissues was selected. The results showed that the average number of conserved segments per intron in autism specific genes was 3.9, while it was 1.4 in the case of the genes minimally expressed in the brain. A non- parametric statistical test (Mann-Witney) showed a significant difference in degree of conservation between the two groups.
Read online Conserved Signals of Ncrna Across 73 Genes Associated with Asd Buy and read online Conserved Signals of Ncrna Across 73 Genes Associated with Asd Download Conserved Signals of Ncrna Across 73 Genes Associated with Asd for pc, mac, kindle, readers Download to iPad/iPhone/iOS, B&N nook Conserved Signals of Ncrna Across 73 Genes Associated with Asd ebook, pdf, djvu, epub, mobi, fb2, zip, rar, torrent
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Download book The French Secret Services : A History of French Intelligence from the Drefus Affair to the Gulf War
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